Skip to main content
SpringerLink
Log in

Protein engineering

Tighter ties that bind

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

A stepwise process of mutation and structural analysis has modulated a flexible binding interface of an immune-cell signalling protein, interleukin-2, and generated mutant proteins with enhanced anticancer activity. See Article p.529

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Signalling superpowers.

References

  1. Levin, A. M. et al. Nature 484, 529–533 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Malek, T. R. & Castro, I. Immunity 33, 153–165 (2010).

    Article  CAS  Google Scholar 

  3. Wang, X., Rickert, M. & Garcia, K. C. Science 310, 1159–1163 (2005).

    Article  ADS  CAS  Google Scholar 

  4. Arima, N. et al. J. Exp. Med. 176, 1265–1272 (1992).

    Article  CAS  Google Scholar 

  5. Eklund, J. W. & Kuzel, T. M. Curr. Opin. Oncol. 16, 542–546 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eric T. Boder is in the Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, Tennessee 37996-2200, USA.,

    Eric T. Boder

Authors
  1. Eric T. Boder
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eric T. Boder.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boder, E. Tighter ties that bind. Nature 484, 463–464 (2012). https://doi.org/10.1038/484463a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/484463a

  • Springer Nature Limited

Search

Navigation