Skip to main content
SpringerLink
Log in

Genetics

Broken giant linked to heart failure

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Genetic mutations can cause a type of heart disease called dilated cardiomyopathy, by predisposing the organ to enlarge and function poorly. It has now been found that 27% of cases are due to mutations that disrupt the muscle protein titin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: A molecular ruler.

References

  1. Dellefave, L. & McNally, E. M. Curr. Opin. Cardiol. 25, 198–204 (2010).

    Article  Google Scholar 

  2. Herman, D. S. et al. N. Engl. J. Med. 366, 619–628 (2012).

    Article  CAS  Google Scholar 

  3. Miller, M. K., Granzier, H., Ehler, E. & Gregorio, C. C. Trends Cell Biol. 14, 119–126 (2004).

    Article  CAS  Google Scholar 

  4. Gerull, B. et al. Nature Genet. 30, 201–204 (2002).

    Article  CAS  Google Scholar 

  5. Gautel, M. Pflügers Arch. 462, 119–134 (2011).

    Article  CAS  Google Scholar 

  6. Nagueh, S. F. et al. Circulation 110, 155–162 (2004).

    Article  CAS  Google Scholar 

  7. Bamshad, M. J. et al. Nature Rev. Genet. 12, 745–755 (2011).

    Article  CAS  Google Scholar 

  8. van Rijsingen, I. A. et al. J. Am. Coll. Cardiol. 59, 493–500 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Elizabeth M. McNally is in the Department of Medicine, and in the Department of Human Genetics, Section of Cardiology, University of Chicago, Chicago, Illinois 60637, USA.,

    Elizabeth M. McNally

Authors
  1. Elizabeth M. McNally
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elizabeth M. McNally.

Ethics declarations

Competing interests

The author’s spouse receives patent royalties related to techniques used in massively parallel sequencing.

Rights and permissions

Reprints and permissions

About this article

Cite this article

McNally, E. Broken giant linked to heart failure. Nature 483, 281–282 (2012). https://doi.org/10.1038/483281a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/483281a

  • Springer Nature Limited

This article is cited by

Search

Navigation