Piezo proteins have been shown to form large ion channels that serve a sensory function in fruitflies. The findings help to explain how Piezos convert mechanical force into biological signals. See Article p.176 & Letter p.209
References
Chalfie, M. Nature Rev. Mol. Cell. Biol. 10, 44–52 (2009).
Coste, B. et al. Science 330, 55–60 (2010).
Coste, B. et al. Nature 483, 176–181 (2012).
Kim, S. E., Coste, B., Chadha, A., Cook, B. & Patapoutian, A. Nature 483, 209–212 (2012).
Guharay, F. & Sachs, F. J. Physiol. (Lond.) 352, 685–701 (1984).
Bae, C., Sachs, F. & Gottlieb, P. A. Biochemistry 50, 6295–6300 (2011).
Honoré, E., Patel, A. J., Chemin, J., Suchyna, T. & Sachs, F. Proc. Natl Acad. Sci. USA 103, 6859–6864 (2006).
Kung, C., Martinac, B. & Sukharev, S. Annu. Rev. Microbiol. 64, 313–329 (2010).
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Gottlieb, P., Sachs, F. The sensation of stretch. Nature 483, 163–164 (2012). https://doi.org/10.1038/483163a
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DOI: https://doi.org/10.1038/483163a
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