Cells package proteins into vesicles for secretion to the extracellular milieu. A study has now identified an enzyme that modifies the packaging machinery to encapsulate unusually large proteins, such as collagen. See Article p.495
References
Zanetti, G., Pahuja, K. B., Studer, S., Shim, S. & Schekman, R. Nat. Cell. Biol. 14, 20–28 (2012).
Jin, L. et al. Nature 482, 495–500 (2012).
Stagg, S. M. et al. Cell 134, 474–484 (2008).
Fath, S., Mancias, J. D., Bi, X. & Goldberg, J. Cell 129, 1325–1336 (2007).
Komander, D. Biochem. Soc. Trans. 37, 937–953 (2009).
Saito, K. et al. Cell 136, 891–902 (2009).
Wilson, D. G. et al. J. Cell Biol. 193, 935–951 (2011).
De Matteis, M. A. & Luini, A. N. Engl. J. Med. 365, 927–938 (2011).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Stephens, D. Collagen secretion explained. Nature 482, 474–475 (2012). https://doi.org/10.1038/482474a
Published:
Issue Date:
DOI: https://doi.org/10.1038/482474a
- Springer Nature Limited
This article is cited by
-
Collagen transport and related pathways in Osteogenesis Imperfecta
Human Genetics (2021)
-
COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling
Journal of Experimental & Clinical Cancer Research (2020)
-
KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis
Scientific Reports (2017)
-
Microscopic and ultrastructural evidences in human skin following calcium hydroxylapatite filler treatment
Archives of Dermatological Research (2017)
-
Microscopic and ultrastructural modifications of postmenopausal atrophic vaginal mucosa after fractional carbon dioxide laser treatment
Lasers in Medical Science (2015)