Compounds containing the trifluoromethyl group have many uses, but their isomers must often be made using different multi-step routes. Two studies now show how several isomers can be made by the same route. See Letter p.224
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References
Muller, K., Faeh, C. & Diederich, F. Science 317, 1881–1886 (2007).
Hiyama, T. Organofluorine Compounds: Chemistry and Applications (Springer, 2000).
Ji, Y. et al. Proc. Natl Acad. Sci. USA 108, 14411–14415 (2011).
Nagib, D. A. & MacMillan, D. W. C. Nature 480, 224–228 (2011).
Tomashenko, O. A. & Grushin, V. V. Chem. Rev. 111, 4475–4521 (2011).
Langlois, B. R., Laurent, E. & Roidot, N. Tetrahedron Lett. 32, 7525–7528 (1991).
Kamigata, N., Fukushima, T. & Yoshida, M. Chem. Lett. 19, 649–650 (1990).
Kamigata, N., Ohtsuka, T., Fukushima, T., Yoshida, M. & Shimizu, T. J. Chem. Soc. Perkin Trans. 1 1339–1346 (1994).
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S.L.B. is a consultant for a company partially owned by David MacMillan. S.L.B. and David MacMillan co-teach a short course that they have given together at pharmaceutical companies.
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Parsons, A., Buchwald, S. A radical approach to diversity. Nature 480, 184–185 (2011). https://doi.org/10.1038/480184a
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DOI: https://doi.org/10.1038/480184a
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