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Many faces of a cancer-supporting protein

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A Correction to this article was published on 26 October 2011

The protein Hsp90 is a target of promising anticancer drugs. An analysis of the components of Hsp90 complexes in tumours reveals a path that may lead to predictive assays of drug sensitivity in cancer patients.

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Figure 1: Analysis of Hsp90-containing complexes using chemical proteomics.

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Authors and Affiliations

  1. John F. Darby and Paul Workman are in the Cancer Research UK Cancer Therapeutics Unit, Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey SM2 5NG, UK.,

    John F. Darby & Paul Workman

Authors
  1. John F. Darby
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  2. Paul Workman
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Correspondence to Paul Workman.

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Competing interests

J.F.D. is a PhD student at and P.W. is an employee of the Institute of Cancer Research, which has a commercial interest in Hsp90 inhibitors. P.W. has been involved in a funded research collaboration on Hsp90 inhibitors with Vernalis Ltd. Intellectual property arising from the Hsp90 programme has been licensed to Vernalis and Novartis. P.W. has been a consultant to Novartis.

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Darby, J., Workman, P. Many faces of a cancer-supporting protein. Nature 478, 334–335 (2011). https://doi.org/10.1038/478334b

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