Skip to main content
SpringerLink
Log in

Cardiovascular biology

Heart fails without pump partner

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Mishandling of calcium ions by cardiac cells causes the heart to malfunction. The discovery of a crucial modification to a calcium pump inside the cell opens up a potential way to correct this. See Letter p.601

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The SERCA2a calcium pump and its modification by SUMO1.

References

  1. Kho, C. et al. Nature 477, 601–605 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Bers, D. M. Nature 415, 198–205 (2002).

    Article  ADS  CAS  Google Scholar 

  3. Cheng, H. & Lederer, W. J. Physiol. Rev. 88, 1491–1545 (2008).

    Article  CAS  Google Scholar 

  4. Rockman, H. A., Koch, W. J. & Lefkowitz, R. J. Nature 415, 206–212 (2002).

    Article  ADS  CAS  Google Scholar 

  5. Shah, A. M. & Mann, D. L. Lancet 378, 704–712 (2011).

    Article  CAS  Google Scholar 

  6. Geiss-Friedlander, R. & Melchior, F. Nature Rev. Mol. Cell Biol. 8, 947–956 (2007).

    Article  CAS  Google Scholar 

  7. Yeh, E. T. H. J. Biol. Chem. 284, 8223–8227 (2009).

    Article  CAS  Google Scholar 

  8. Matunis, M. J. & Pickart, C. M. Nature Struct. Mol. Biol. 12, 565–566 (2005).

    Article  CAS  Google Scholar 

  9. Wang, J. & Schwartz, R. J. Circulation Res. 107, 19–29 (2010).

    Article  CAS  Google Scholar 

  10. Plant, L. D. et al. Proc. Natl Acad. Sci. USA 107, 10743–10748 (2010).

    Article  ADS  CAS  Google Scholar 

  11. Benson, M. D. et al. Proc. Natl Acad. Sci. USA 104, 1805–1810 (2007).

    Article  ADS  CAS  Google Scholar 

  12. Stade, K. et al. J. Biol. Chem. 277, 49554–49561 (2002).

    Article  CAS  Google Scholar 

  13. Shenoy, S. K. & Lefkowitz, R. J. Trends Pharmacol. Sci. 32, 521–533 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sudha K. Shenoy and Howard A. Rockman are in the Departments of Medicine, Cell Biology, and Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.,

    Sudha K. Shenoy & Howard A. Rockman

Authors
  1. Sudha K. Shenoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Howard A. Rockman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Sudha K. Shenoy or Howard A. Rockman.

Ethics declarations

Competing interests

H.A.R. is a scientific co-founder of and consultant for Trevena Inc., a company that is developing G-protein-coupled-receptor-targeted drugs.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shenoy, S., Rockman, H. Heart fails without pump partner. Nature 477, 546–547 (2011). https://doi.org/10.1038/477546a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/477546a

  • Springer Nature Limited

Search

Navigation