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Stem cells

iPS cells under attack

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Induced pluripotent stem cells offer promise for patient-specific regenerative therapy. But a study now cautions that, even when immunologically matched, these cells can be rejected after transplantation. See Letter p.212

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Figure 1: Immunogenicity of induced pluripotent stem cells.

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Authors and Affiliations

  1. USA. They are also in the Department of Stem Cell and Regenerative Biology, Effie Apostolou and Konrad Hochedlinger are at the Howard Hughes Medical Institute, Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, and at the Harvard Stem Cell Institute, Harvard University.,

    Effie Apostolou & Konrad Hochedlinger

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  1. Effie Apostolou
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  2. Konrad Hochedlinger
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Correspondence to Konrad Hochedlinger.

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Competing interests

K.H. is an adviser to iPerian, Inc.

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Apostolou, E., Hochedlinger, K. iPS cells under attack. Nature 474, 165–166 (2011). https://doi.org/10.1038/474165a

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