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The flipside of Notch

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Mutations that lead to increased activity of the Notch signalling pathway are well defined in human cancer. New work implicates decreased activity of this pathway in a type of blood cancer. See Letter p.230

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Figure 1: The Notch signalling pathway and blood disorders.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Demetrios Kalaitzidis and Scott A. Armstrong are at Children's Hospital Boston, and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.,

    Demetrios Kalaitzidis & Scott A. Armstrong

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  1. Demetrios Kalaitzidis
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  2. Scott A. Armstrong
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Correspondence to Demetrios Kalaitzidis or Scott A. Armstrong.

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Kalaitzidis, D., Armstrong, S. The flipside of Notch. Nature 473, 159–160 (2011). https://doi.org/10.1038/473159a

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