Generation of complex organs in vitro is a major challenge in regenerative medicine. But it is not an impossible one: an entire synthetic retina has now been generated from embryonic stem cells. See Article p.51
References
Eiraku, M. et al. Nature 472, 51–56 (2011).
Zuber, M. E., Gestri, G., Viczian, A. S., Barsacchi, G. & Harris, W. A. Development 130, 5155–5167 (2003).
Lamba, D. A., Karl, M. O., Ware, C. B. & Reh, T. A. Proc. Natl Acad. Sci. USA 103, 12769–12774 (2006).
Osakada, F. et al. Nature Biotechnol. 26, 215–224 (2008).
Yang, C. et al. FASEB J. 24, 3274–3283 (2010).
Meyer, J. S. et al. Proc. Natl Acad. Sci. USA 106, 16698–16703 (2009).
Ikeda, H. et al. Proc. Natl Acad. Sci. USA 102, 11331–11336 (2005).
MacLaren, R. E. et al. Nature 444, 203–207 (2006).
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Ali, R., Sowden, J. DIY eye. Nature 472, 42–43 (2011). https://doi.org/10.1038/472042a
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DOI: https://doi.org/10.1038/472042a
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