Genome-wide association studies are often criticized for providing little insight of immediate physiological relevance. The finding of one such study, which implicates a signalling molecule in schizophrenia, is welcome news. See Letter p.499
References
van Os, J. & Kapur, S. Lancet 374, 635–645 (2009).
Vacic, V. et al. Nature 471, 499–503 (2011).
Howes, O. D. & Kapur, S. Schizophrenia Bull. 35, 549–562 (2009).
Tam, G. W. C., Redon, R., Carter, N. P. & Grant, S. G. N. Biol. Psychiatry 66, 1005–1012 (2009).
Mulle, J. G. et al. Am. J. Hum. Genet. 87, 229–236 (2010).
Moody, T. W. et al. Curr. Opin. Endocrinol. Diabetes Obesity 18, 61–67 (2011).
Brown, T. M., Hughes, A. T. & Piggins, H. D. J. Neurosci. 25, 11155–11164 (2005).
Pierre, S., Eschenhagen, T., Geisslinger, G. & Scholich, K. Nature Rev. Drug Discov. 8, 321–335 (2009).
Chaudhury, D. et al. BMC Neurosci. 9, 63 (2008).
Hughes, A. T., Fahey, B., Cutler, D. J., Coogan, A. N. & Piggins, H. D. J. Neurosci. 24, 3522–3526 (2004).
Sheward, W. J. et al. PLoS ONE 5, e9783 (2010).
Levinson, D. F. et al. Am. J. Psychiatry 168, 302–316 (2011).
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Piggins, H. Zooming in on a gene. Nature 471, 455–456 (2011). https://doi.org/10.1038/471455a
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DOI: https://doi.org/10.1038/471455a
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