Metathesis reactions can be used to make carbon–carbon double bonds — bar one isomeric class. By using new catalysts and balancing out the stabilities of intermediates in the reaction, the elusive isomers can be made. See Article p.461
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References
Meek, S. J., O'Brien, R. V., Llaveria, J., Schrock, R. R. & Hoveyda, A. H. Nature 471, 461–466 (2011).
Crowe, W. E. & Goldberg, D. R. J. Am. Chem. Soc. 117, 5162–5163 (1995).
Solans-Monfort, X., Clot, E., Copéret, C. & Eisenstein, O. J. Am. Chem. Soc. 127, 14015–14025 (2005).
Ibrahem, I., Yu, M., Schrock, R. R. & Hoveyda, A. H. J. Am. Chem. Soc. 131, 3844–3845 (2009).
Chatterjee, A. K., Choi, T.-L., Sanders, D. P. & Grubbs, R. H. J. Am. Chem. Soc. 125, 11360–11370 (2003).
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Lee, D. Overcoming catalytic bias. Nature 471, 452–453 (2011). https://doi.org/10.1038/471452a
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DOI: https://doi.org/10.1038/471452a
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