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Circadian rhythms

Redox redux

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Oscillations in gene transcription that occur in response to biological daily clocks coordinate the physiological workings of living organisms. But turnover in cellular energy may be sufficient to make the clock tick. See Article p.498 & Letter p.554

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Figure 1: Coupling of genetic and metabolic clocks.

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Authors and Affiliations

  1. Joseph Bass is in the Division of Endocrinology and Molecular Medicine, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. He is also at the Center for Sleep and Circadian Biology, Northwestern University, Evanston. j-bass@northwestern.edu,

    Joseph Bass

  2. Joseph S. Takahashi is in the Department of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111, USA.,

    Joseph S. Takahashi

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  1. Joseph Bass
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  2. Joseph S. Takahashi
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Competing interests

J.B. declares competing financial interests. He is a speaker and consultant for Merck and for GLG; has received research awards from Amylin Pharmaceuticals and Eli Lilly and from Takeda Pharmaceuticals; and owns stock and is on the advisory board of Reset Therapeutics.

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Bass, J., Takahashi, J. Redox redux. Nature 469, 476–478 (2011). https://doi.org/10.1038/469476a

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