Tumour stem cells are proposed to be the source of tumour cells. It now emerges that they also give rise to the endothelial cells that line the tumour vasculature, mediating tumour growth and metastasis. See Letters p.824 & p.829
References
Hanahan, D. & Folkman, J. Cell 86, 353–364 (1996).
Wang, R. et al. Nature 468, 829–833 (2010).
Ricci-Vitiani, L. et al. Nature 468, 824–828 (2010).
Hendrix, M. J. C., Seftor, E. A., Hess, A. R. & Seftor, R. E. B. Nature Rev. Cancer 3, 411–421 (2003).
El Hallani, S. et al. Brain 133, 973–982 (2010).
Lathia, J. D., Venere, M., Rao, M. S. & Rich, J. N. Stem Cell Rev. Rep. doi:10.1007/s12105-010-9194-6 (2010).
Dong, J. et al. Stem Cell Rev. Rep. doi:10.1007/s12105-010-9169-7 (2010).
Streubel, B. et al. N. Engl. J. Med. 351, 250–259 (2004).
Pezzolo, A. et al. J. Clin. Oncol. 25, 376–383 (2007).
Hida, K. et al. Cancer Res. 64, 8249–8255 (2004).
Akino, T. et al. Am. J. Pathol. 175, 2657–2667 (2009).
Taylor, S. M. et al. Blood 116, 3108–3117 (2010).
Dudley, A. C. et al. Cancer Cell 14, 201–211 (2008).
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Bautch, V. Tumour stem cells switch sides. Nature 468, 770–771 (2010). https://doi.org/10.1038/468770a
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DOI: https://doi.org/10.1038/468770a
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