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Protein factors can regulate gene expression by binding to specifically modified DNA-associated proteins. Small molecules that selectively interfere with such interaction may be of therapeutic value. See Article p.1067 & Letter p.1119

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Figure 1: Targeting the interaction between bromodomains and acetyl-lysine moieties.

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Authors and Affiliations

  1. Sean D. Taverna and Philip A. Cole are in the Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.,

    Sean D. Taverna & PhiliP A. Cole

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  1. Sean D. Taverna
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  2. PhiliP A. Cole
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Taverna, S., Cole, P. Reader's block. Nature 468, 1050–1051 (2010). https://doi.org/10.1038/4681050a

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