Spikes on the surface of HIV to which antibodies can bind are sparse. One of nature's solutions is to sometimes produce antibodies that bind tightly to a spike with one arm and grab another structure with the other arm. See Letter p.591
References
Mouquet, H. et al. Nature 467, 591–595 (2010).
Pancera, M. et al. Proc. Natl Acad. Sci. USA 107, 1166–1171 (2010).
Zhu, P. et al. Nature 441, 847–852 (2006).
Yuste, E., Johnson, W., Pavlakis, G. N. & Desrosiers, R. C. J. Virol. 79, 12455–12463 (2005).
Karlsson Hedestam, G. B. et al. Nature Rev. Microbiol. 6, 143–155 (2008).
Cavacini, L. A., Emes, C. L., Power, J., Duval, M. & Posner, M. R. J. Immunol. 152, 2538–2545 (1994).
Klasse, P. J. & Sattentau, Q. J. Curr. Top. Microbiol. Immunol. 260, 87–108 (2001).
Crothers, D. M. & Metzger, H. Immunochemistry 9, 341–357 (1972).
James, L. C., Roversi, P. & Tawfik, D. S. Science 299, 1362–1367 (2003).
Bostrom, J. et al. Science 323, 1610–1614 (2009).
Haynes, B. F. et al. Science 308, 1906–1908 (2005).
Walker, L. M. et al. Science 326, 285–289 (2009).
Scherer, E. M., Zwick, M. B., Teyton, L. & Burton, D. R. AIDS 21, 2131–2139 (2007).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Plückthun, A. Antibodies with a split personality. Nature 467, 537–538 (2010). https://doi.org/10.1038/467537a
Published:
Issue Date:
DOI: https://doi.org/10.1038/467537a
- Springer Nature Limited
This article is cited by
-
Capturing transient antibody conformations with DNA origami epitopes
Nature Communications (2020)
-
Molecular imaging with nanoparticles: the dwarf actors revisited 10 years later
Histochemistry and Cell Biology (2018)