Stem cells can renew themselves indefinitely — a feature that is often attributed to asymmetrical cell division. Fresh experimental and mathematical models of the intestine provide evidence that begs to differ.
This is a preview of subscription content, log in via an institution to check access.
References
Fuller, M. T. & Spradling, A. C. Science 316, 402–404 (2007).
Knoblich, J. A. Cell 132, 583–597 (2008).
Lopez-Garcia, C., Klein, A. M., Simons, B. D. & Winton, D. J. Science doi:10.1126/science.1196236 (2010).
Snippert, H. J. et al. Cell 143, 134–144 (2010).
Sangiorgi, E. & Capecchi, M. R. Nature Genet. 40, 915–920 (2008).
Barker, N. et al. Nature 449, 1003–1007 (2007).
Sato, T. et al. Nature 459, 262–265 (2009).
Winton, D. J., Blount, M. A. & Ponder, B. A. J. Nature 333, 463–466 (1988).
Bramson, M. & Griffeath, D. Probab. Theor. Relat. Fields 53, 183–196 (1980).
Li, L. & Clevers, H. Science 327, 542–545 (2010).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Verzi, M., Shivdasani, R. The intestinal–crypt casino. Nature 467, 1055–1056 (2010). https://doi.org/10.1038/4671055a
Published:
Issue Date:
DOI: https://doi.org/10.1038/4671055a
- Springer Nature Limited
This article is cited by
-
A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments
Theoretical Biology and Medical Modelling (2013)