Cocaine abuse results in increased craving for the drug. But in the long run, cocaine intake induces the expression of a microRNA in the brain, and this seems to limit further drug intake.
This is a preview of subscription content, log in via an institution to check access.
References
Hollander, J. A. et al. Nature 466, 197–202 (2010).
Nestler, E. J. Neuropharmacology 47 (suppl.), 24–32 (2004).
Turrigiano, G. G. Trends Neurosci. 22, 221–227 (1999).
Lee, R. C., Feinbaum, R. L. & Ambros, V. Cell 75, 843–854 (1993).
Reinhart, B. J. et al. Nature 403, 901–906 (2000).
Bentwich, I. et al. Nature Genet. 37, 766–770 (2005).
Carlezon, W. A. et al. Science 282, 2272–2275 (1998).
Dong, Y. et al. Nature Neurosci. 9, 475–477 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Picciotto, M. MicroRNA knocks down cocaine. Nature 466, 194–195 (2010). https://doi.org/10.1038/466194a
Published:
Issue Date:
DOI: https://doi.org/10.1038/466194a
- Springer Nature Limited