Infection with hepatitis C is one of the main causes of liver disease, yet there are no broadly effective treatments. Discovery of a potent inhibitor of this virus shows that researchers must think outside the box.
References
Gao, M. et al. Nature 465, 96–100 (2010).
Ge, D. et al. Nature 461, 399–401 (2009).
Suppiah, V. et al. Nature Genet. 41, 1100–1104 (2009).
Tanaka, Y. et al. Nature Genet. 41, 1105–1109 (2009).
De Francesco, R. & Migliaccio, G. Nature 436, 953–960 (2005).
Kwong, A. D., McNair, L., Jacobson, I. & George, S. Curr. Opin. Pharmacol. 8, 522–531 (2008).
Lemm, J. A. et al. J. Virol. 84, 482–491 (2010).
Tellinghuisen, T. L., Foss, K. L. & Treadaway, J. PLoS Pathog. 4, e1000032 (2008).
Appel, N. et al. PLoS Pathog. 4, e1000035 (2008).
Tellinghuisen, T. L., Marcotrigiano, J. & Rice, C. M. Nature 435, 374–379 (2005).
Love, R. A., Brodsky, O., Hickey, M. J., Wells, P. A. & Cronin, C. N. J. Virol. 83, 4395–4403 (2009).
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Murray, C., Rice, C. An unsuspected drug target. Nature 465, 43–44 (2010). https://doi.org/10.1038/465042a
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DOI: https://doi.org/10.1038/465042a
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