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A brake on lipid synthesis

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Although sphingolipids are vital cellular components, the path to their production is paved with toxic intermediates. Orm proteins allow cells to form these lipids without killing themselves in the process.

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Figure 1: Orm proteins control sphingolipid homeostasis in the endoplasmic reticulum.

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Authors and Affiliations

  1. Fikadu G. Tafesse and Joost C. M. Holthuis are in the Bijvoet Center and the Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, the Netherlands. j.c.holthuis@uu.nl ,

    Fikadu G. Tafesse & Joost C. M. Holthuis

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  1. Fikadu G. Tafesse
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  2. Joost C. M. Holthuis
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Tafesse, F., Holthuis, J. A brake on lipid synthesis. Nature 463, 1028–1029 (2010). https://doi.org/10.1038/4631028a

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