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DNA Replication

Prime-time looping

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When the replication machinery copies DNA, it must unwind the double helix in one direction while synthesis of one of the strands proceeds in the other. Making transient DNA loops may solve this directional dilemma.

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Figure 1: DNA replication by a minimal replisome.
Figure 2: Three priming mechanisms.

References

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Authors and Affiliations

  1. Nicholas E. Dixon is at the School of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia. nickd@uow.edu.au ,

    Nicholas E. Dixon

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  1. Nicholas E. Dixon
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Dixon, N. Prime-time looping. Nature 462, 854–855 (2009). https://doi.org/10.1038/462854a

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