Skip to main content
SpringerLink
Log in

Ageing

A midlife longevity drug?

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The small molecule rapamycin, already approved for clinical use for various human disorders, has been found to significantly increase lifespan in mice. Is this a step towards an anti-ageing drug for people?

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Rapa Nui and rapamycin.

H. KANUS/SPL

References

  1. Harrison, D. E. et al. Nature 460, 392–395 (2009).

    Article  CAS  ADS  Google Scholar 

  2. Jia, K., Chen, D. & Riddle, D. L. Development 131, 3897–3906 (2004).

    Article  CAS  Google Scholar 

  3. Kaeberlein, M. et al. Science 310, 1193–1196 (2005).

    Article  CAS  ADS  Google Scholar 

  4. Kapahi, P. et al. Curr. Biol. 14, 885–890 (2004).

    Article  CAS  Google Scholar 

  5. Powers, R. W. 3rd, Kaeberlein, M., Caldwell, S. D., Kennedy, B. K. & Fields, S. Genes Dev. 20, 174–184 (2006).

    Article  CAS  Google Scholar 

  6. Vellai, T. et al. Nature 426, 620 (2003).

    Article  CAS  ADS  Google Scholar 

  7. Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. & Kennedy, B. K. Biochim. Biophys. Acta advance online publication doi:10.1016/j.bbagen.2009.06.007 (2009).

  8. Smith, E. D. et al. Genome Res. 18, 564–570 (2008).

    Article  CAS  Google Scholar 

  9. Steffen, K. K. et al. Cell 133, 292–302 (2008).

    Article  CAS  Google Scholar 

  10. Hansen, M. et al. PLoS Genet. 4, e24 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Matt Kaeberlein and Brian K. Kennedy are in the Departments of Pathology and Biochemistry, University of Washington, Seattle, Washington 98195, USA. kaeber@u.washington.edu,

    Matt Kaeberlein & Brian K. Kennedy

Authors
  1. Matt Kaeberlein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brian K. Kennedy
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

M.K. and B.K.K. have patents pending for high-throughput methods for measuring lifespan in yeast.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaeberlein, M., Kennedy, B. A midlife longevity drug?. Nature 460, 331–332 (2009). https://doi.org/10.1038/460331a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/460331a

  • Springer Nature Limited

This article is cited by

Search

Navigation