When starved, cells resort to breaking down their assets — proteins, lipids and even whole organelles. An investigation of lipid metabolism indicates that one process — autophagy — targets all three cellular components.
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References
Martin, S. & Parton, R. G. Nature Rev. Mol. Cell Biol. 7, 373–378 (2006).
Singh, R. et al. Nature 458, 1131–1135 (2009).
Levine, B. & Kroemer, G. Cell 132, 27–42 (2008).
Zechner, R. et al. J. Lipid Res. 50, 3–21 (2009).
Opipari, A. W. Jr et al. Cancer Res. 64, 696–703 (2004).
Baur, J. A. et al. Nature 444, 337–342 (2006).
Brasaemle, D. L. J. Lipid Res. 48, 2547–2559 (2007).
Kuriwaki, K. & Yoshida, H. Pathol. Int. 49, 291–297 (1999).
Hayashi, H., Sameshima, Y., Lee, M., Hotta, Y. & Kosaka, T. Hepatology 3, 221–225 (1983).
Shibata, M. et al. Biochem. Biophys. Res. Commun. 382, 419–423 (2009).
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Zechner, R., Madeo, F. Another way to get rid of fat. Nature 458, 1118–1119 (2009). https://doi.org/10.1038/4581118a
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DOI: https://doi.org/10.1038/4581118a
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