Cells of the adaptive immune system hold a grudge: on re-encountering a pathogen, they show a robust protective response. It seems that natural killer cells of the innate immune system might also have this ability.
References
Gourley, T. S. et al. Semin. Immunol. 16, 323–333 (2004).
Sun, J. C., Beilke, J. N. & Lanier, L. L. Nature 457, 557–561 (2009).
Pancer, Z. & Cooper, M. D. Annu. Rev. Immunol. 24, 497–518 (2006).
Vivier, E. et al. Nature Immunol. 9, 503–510 (2008).
Smith, H. R. et al. Proc. Natl Acad. Sci. USA 99, 8826–8831 (2002).
Arase, H. et al. Science 296, 1323–1326 (2002).
Dokun, A. O. et al. Nature Immunol. 2, 951–956 (2001).
Selin, L. K. et al. Immunol. Rev. 211, 164–181 (2006).
Glas, R. et al. J. Exp. Med. 191, 129–138 (2000).
Raulet, D. H. Nature Immunol. 5, 996–1002 (2004).
Raulet, D. H. & Vance, R. E. Nature Rev. Immunol. 6, 520–531 (2006).
Lucas, M. et al. Immunity 26, 503–517 (2007).
Vivier, E. & Malissen, B. Nature Immunol. 6, 17–21 (2005).
Zinkernagel, R. M. & Hengartner, H. Immunol. Rev. 211, 310–319 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ugolini, S., Vivier, E. Natural killer cells remember. Nature 457, 544–545 (2009). https://doi.org/10.1038/457544a
Published:
Issue Date:
DOI: https://doi.org/10.1038/457544a
- Springer Nature Limited
This article is cited by
-
Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation
Scientific Reports (2019)
-
Learning in a simple biological system: a pilot study of classical conditioning of human macrophages in vitro
Behavioral and Brain Functions (2011)