Skip to main content
SpringerLink
Log in

Molecular biology

Concealed enzyme coordination

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Coordination between subunits is crucial for the proper functioning of multi-component molecular machines. A single-molecule study now allows glimpses into the mechanism used by subunits of one such machine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Proposed coordination mechanisms of ring ATPases.
Figure 2: Analysis of DNA translocation by the bacteriophage φ29 motor.

References

  1. Erzberger, J. P. & Berger, J. M. Annu. Rev. Biophys. Biomol. Struct. 35, 93–114 (2006).

    Article  CAS  Google Scholar 

  2. Moffitt, J. R. et al. Nature 457, 446–450 (2009).

    Article  ADS  CAS  Google Scholar 

  3. Adachi, K. et al. Cell 130, 309–321 (2007).

    Article  CAS  Google Scholar 

  4. Gai, D., Zhao, R., Li, D., Finkielstein, C. V. & Chen, X. S. Cell 119, 47–60 (2004).

    Article  CAS  Google Scholar 

  5. Martin, A., Baker, T. A. & Sauer, R. T. Nature 437, 1115–1120 (2005).

    Article  ADS  CAS  Google Scholar 

  6. Abbondanzieri, E. A., Greenleaf, W. J., Shaevitz, J. W., Landick, R. & Block, S. M. Nature 438, 460–465 (2005).

    Article  ADS  CAS  Google Scholar 

  7. Moffitt, J. R., Chemla, Y. R., Izhaky, D. & Bustamante, C. Proc. Natl Acad. Sci. USA 103, 9006–9011 (2006).

    Article  ADS  CAS  Google Scholar 

  8. Smith, D. E. et al. Nature 413, 748–752 (2001).

    Article  ADS  CAS  Google Scholar 

  9. Guo, P., Peterson, C. & Anderson, D. J. Mol. Biol. 197, 229–236 (1987).

    Article  CAS  Google Scholar 

  10. Chemla, Y. R. et al. Cell 122, 683–692 (2005).

    Article  CAS  Google Scholar 

  11. Nishizaka, T. et al. Nature Struct. Mol. Biol. 11, 142–148 (2004).

    Article  CAS  Google Scholar 

  12. Adelman, J. L. et al. Mol. Cell 22, 611–621 (2006).

    Article  CAS  Google Scholar 

  13. Cecconi, C., Shank, E. A., Bustamante, C. & Marqusee, S. Science 309, 2057–2060 (2005).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Elio A. Abbondanzieri and Xiaowei Zhuang are at the Howard Hughes Medical Institute and Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. zhuang@chemistry.harvard.edu ,

    Elio A. Abbondanzieri & Xiaowei Zhuang

Authors
  1. Elio A. Abbondanzieri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaowei Zhuang
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Abbondanzieri, E., Zhuang, X. Concealed enzyme coordination. Nature 457, 392–393 (2009). https://doi.org/10.1038/457392a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/457392a

  • Springer Nature Limited

Search

Navigation