An analysis of neuronal proteins reveals that many are regulated through covalent attachment of the lipid palmitate. This reversible modification seems to affect the form and function of synaptic junctions.
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References
Kang, R. et al. Nature 456, 904–909 (2008).
Roth, A. F. et al. Cell 125, 1003–1013 (2006).
Drisdel, R. C. & Green, W. N. Biotechniques 36, 276–285 (2004).
Ethell, I. M. & Pasquale, E. B. Prog. Neurobiol. 75, 161–205 (2005).
Marks, P. W. & Kwiatkowski, D. J. Genomics 38, 13–18 (1996).
Hering, H., Lin, C. C. & Sheng, M. J. Neurosci. 23, 3262–3271 (2003).
Smotrys, J. E. & Linder, M. E. Annu. Rev. Biochem. 73, 559–587 (2004).
Halpain, S., Hipolito, A. & Saffer, L. J. Neurosci. 18, 9835–9844 (1998).
Tsutsumi, R., Fukata, Y. & Fukata, M. Pflügers Arch. 456, 1199–1206 (2008).
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Linder, M. Greasy proteins of the neuron. Nature 456, 887–888 (2008). https://doi.org/10.1038/456887a
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DOI: https://doi.org/10.1038/456887a
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