Early middle age is a difficult time, not least for male fruitflies when sperm production falls. The unexpected reason for this decline seems to be that, as tissues age, maintaining functional stem cells becomes difficult.
References
Cheng, J. et al. Nature 456, 599–604 (2008).
Jacob, F. Science 196, 1161–1166 (1977).
Yamashita, Y. M., Jones, D. L. & Fuller, M. T. Science 301, 1547–1550 (2003).
Yamashita, Y. M., Mahowald, A. P., Perlin, J. R. & Fuller, M. T. Science 315, 518–521 (2007).
Rebollo, E. et al. Dev. Cell 12, 467–474 (2007).
Rusan, N. M. & Peifer, M. J. Cell Biol. 177, 13–20 (2007).
Boyle, M., Wong, C., Rocha, M. & Jones, D. L. Cell Stem Cell 1, 470–478 (2007).
Wallenfang, M. R., Nayak, R. & DiNardo, S. Aging Cell 5, 297–304 (2006).
Kai, T. & Spradling, A. Nature 428, 564–569 (2004).
Brawley, C. & Matunis, E. Science 304, 1331–1334 (2004).
Clermont, Y. & Bustos-Obregon, E. Am. J. Anat. 122, 237–247 (1968).
Nakagawa, T., Nabeshima, Y.-i. & Yoshida, S. Dev. Cell 12, 195–206 (2007).
Morrison, S. J. & Spradling, A. C. Cell 132, 598–611 (2008).
Pan, L. et al. Cell Stem Cell 1, 458–469 (2007).
Xie, T. & Spradling, A. C. Science 290, 328–330 (2000).
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Spradling, A. Makeshift sperm production. Nature 456, 583–585 (2008). https://doi.org/10.1038/456583a
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DOI: https://doi.org/10.1038/456583a
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