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Organic chemistry

Short cuts to complexity

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The credit crunch is forcing people to tighten their belts, but chemists have long known the benefits of being economical with atoms. The latest synthesis of an anticancer agent shows how effective parsimony can be.

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Figure 1: The natural source of bryostatins.

SOUTHEASTERN REGIONAL TAXONOMIC CENTER/SOUTH CAROLINA DEPT NAT. RES.

Figure 2: Catalytic steps in the synthesis of bryostatin 16.

References

  1. Banerjee, S. et al. J. Nat. Prod. 71, 492–496 (2008).

    Article  CAS  Google Scholar 

  2. Trost, B. M. & Dong, G. Nature 456, 485–488 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Pettit, G. R. J. Nat. Prod. 59, 812–821 (1996).

    Article  CAS  Google Scholar 

  4. Hongpaisan, J. & Alkon, D. L. Proc. Natl Acad. Sci. USA 104, 19571–19576 (2007).

    Article  ADS  CAS  Google Scholar 

  5. Kageyama, M. et al. J. Am. Chem. Soc. 112, 7407–7408 (1990).

    Article  CAS  Google Scholar 

  6. Evans, D. A. et al. J. Am. Chem. Soc. 121, 7540–7552 (1999).

    Article  CAS  Google Scholar 

  7. Ohmori, K. et al. Angew. Chem. Int. Edn 39, 2290–2294 (2000).

    Article  CAS  Google Scholar 

  8. Trost, B. M. et al. Org. Lett. 7, 4761–4764 (2005).

    Article  CAS  Google Scholar 

  9. Trost, B. M. & Frontier, A. J. J. Am. Chem. Soc. 122, 11727–11728 (2000).

    Article  CAS  Google Scholar 

  10. Gorin, D. J. & Toste, F. D. Nature 446, 395–403 (2007).

    Article  ADS  CAS  Google Scholar 

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Charette, A. Short cuts to complexity. Nature 456, 452–453 (2008). https://doi.org/10.1038/456451a

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