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Apoptosis

Stabbed in the BAX

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Apoptotic cell death is an intricate and highly regulated process. To initiate apoptosis, the protein BIM binds to a hitherto unrecognized site on the BAX protein to trigger permeabilization of the outer mitochondrial membrane.

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Figure 1: Activation of the BAX protein by the BIM SAHB domain.
Figure 2: Possible consequences of BIM SAHB binding to BAX.

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Green, D., Chipuk, J. Stabbed in the BAX. Nature 455, 1047–1049 (2008). https://doi.org/10.1038/4551047a

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