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Oxysterols hold T cells in check

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The oxysterol-dependent gene transcription factor LXRβ restricts premature expansion of T cells by limiting cellular cholesterol levels. This pathway might be a pharmacological target for regulating immune responses.

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Figure 1: Response of T cells to a shift in cholesterol balance.

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Authors and Affiliations

  1. Christopher K. Glass and Kaoru Saijo are in the Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093-0651, USA. ckg@ucsd.edu; ksaijo@ucsd.edu,

    Christopher K. Glass & Kaoru Saijo

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  1. Christopher K. Glass
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  2. Kaoru Saijo
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Glass, C., Saijo, K. Oxysterols hold T cells in check. Nature 455, 40–41 (2008). https://doi.org/10.1038/455040a

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