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Biochemistry

Fit for an enzyme

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Certain enzymes that synthesize antibiotics play a game of pass the parcel, handing biosynthetic intermediates from one active site to another. A study reveals the dynamic nature of interactions between the enzyme domains.

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Figure 1: Protein–protein interactions in megasynthase enzymes.

References

  1. Frueh, D. P. et al. Nature 454, 903–906 (2008).

    Article  ADS  CAS  Google Scholar 

  2. Koglin, A. et al. Nature 454, 907–911 (2008).

    Article  ADS  CAS  Google Scholar 

  3. Tang, Y., Kim, C.-Y., Mathews, I. I., Cane, D. E. & Khosla, C. Proc. Natl Acad. Sci. USA 103, 11124–11129 (2006).

    Article  ADS  CAS  Google Scholar 

  4. Tanovic, A. et al. Science 321, 659–663 (2008).

    Article  ADS  CAS  Google Scholar 

  5. Jenni, S. et al. Science 316, 254–261 (2007).

    Article  ADS  CAS  Google Scholar 

  6. Wolf-Watz, M. et al. Nature Struct. Mol. Biol. 11, 945–949 (2004).

    Article  CAS  Google Scholar 

  7. Henzler-Wildman, K. A. et al. Nature 450, 913–916 (2007).

    Article  ADS  CAS  Google Scholar 

  8. Koglin, A. et al. Science 312, 273–276 (2006).

    Article  ADS  CAS  Google Scholar 

  9. Kumar, S. et al. Protein Sci. 9, 10–19 (2000).

    Article  CAS  Google Scholar 

  10. Grünberg, R., Leckner, J. & Nilges, M. Structure 12, 2125–2136 (2004).

    Article  Google Scholar 

  11. Khosla, C. et al. Annu. Rev. Biochem. 76, 195–221 (2007).

    Article  CAS  Google Scholar 

  12. Lai, J. R., Koglin, A. & Walsh, C. T. Biochemistry 45, 14869–14879 (2006).

    Article  CAS  Google Scholar 

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Kapur, S., Khosla, C. Fit for an enzyme. Nature 454, 832–833 (2008). https://doi.org/10.1038/454832a

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