A mother's instinct is to protect her children at any cost. In the budding yeast Saccharomyces cerevisiae this 'maternal instinct' comes at a high price — accelerated ageing and premature death.
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References
Steinkraus, K. A., Kaeberlein, M. & Kennedy, B. Annu. Rev. Cell Dev. Biol. doi:10.1146/annurev.cellbio.23.090506.123509 (2008).
Egilmez, N. K. & Jazwinski, S. M. J. Bacteriol. 171, 37–42 (1989).
Kennedy, B. K., Austriaco, N. R. Jr & Guarente, L. J. Cell Biol. 127, 1985–1993 (1994).
Shcheprova, Z., Baldi, S., Buvelot Frei, S., Gonnet, G. & Barral, Y. Nature 454, 728–734 (2008).
Sinclair, D. A. & Guarente, L. Cell 91, 1033–1042 (1997).
Aguilaniu, H. et al. Science 299, 1751–1753 (2003).
Erjavec, N., Larsson, L., Grantham, J. & Nyström, T. Genes Dev. 21, 2410–2421 (2007).
Lai, C.-Y., Jaruga, E., Borghouts, C. & Jazwinski, S. M. Genetics 162, 73–87 (2002).
Luedeke, C. et al. J. Cell Biol. 169, 897–908 (2005).
Smith, E. D. et al. Genome Res. 18, 564–570 (2008).
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Kaeberlein, M. A molecular age barrier. Nature 454, 709–710 (2008). https://doi.org/10.1038/454709a
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DOI: https://doi.org/10.1038/454709a
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