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Pharmacology

Unready for action

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Boy scouts recognize that the key to success is to be prepared. The same is true of molecules that bind to and open ion channels — the least effective ones are slower to prepare the channel to be ready for opening.

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Figure 1: Models for partial agonism.

References

  1. Lape, R., Colquhoun, D. & Sivilotti, L. G. Nature 454, 722–727 (2008).

    Article  ADS  CAS  Google Scholar 

  2. del Castillo, J. & Katz, B. Proc. R. Soc. Lond. B Biol. Sci. 146, 362–368 (1957).

    Article  ADS  CAS  Google Scholar 

  3. Burzomato, V. et al. J. Neurosci. 24, 10924–10940 (2004).

    Article  CAS  Google Scholar 

  4. Bafna, P. A., Purohit, P. G. & Auerbach, A. PLoS ONE 3, e2515 (2008).

    Article  ADS  Google Scholar 

  5. Auerbach, A. Proc. Natl Acad. Sci. USA 102, 1408–1412 (2005).

    Article  ADS  CAS  Google Scholar 

  6. Grosman, C., Zhou, M. & Auerbach, A. Nature 403, 773–776 (2000).

    Article  ADS  CAS  Google Scholar 

  7. Plested, A. J. R. et al. J. Physiol. (Lond.) 581, 51–73 (2007).

    Article  CAS  Google Scholar 

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Steinbach, J. Unready for action. Nature 454, 704–705 (2008). https://doi.org/10.1038/454704a

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