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Systems biology

On the cell cycle and its switches

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For the cell-division cycle to progress, hundreds of genes and proteins must be coordinately regulated. Systems-level studies of this cycle show that positive-feedback loops help to keep events in sync.

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Figure 1: Cell-cycle synchronizers.

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Authors and Affiliations

  1. Silvia D. M. Santos and James E. Ferrell are in the Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305–5174, USA. james.ferrell@stanford.edu,

    Silvia D. M. Santos & James E. Ferrell

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  1. Silvia D. M. Santos
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  2. James E. Ferrell
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Santos, S., Ferrell, J. On the cell cycle and its switches. Nature 454, 288–289 (2008). https://doi.org/10.1038/454288a

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