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Modelling collagen diseases

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Mutations in collagen lead to hereditary disorders such as brittle-bone disease. Peptide models for aberrant collagens are beginning to clarify how these amino-acid replacements lead to clinical problems.

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Figure 1: Collagen mutations mimicked by peptide models.

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Authors and Affiliations

  1. Barbara Brodsky is in the Department of Biochemistry, University of Medicine and Dentistry of New Jersey — Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA. brodsky@umdnj.edu,

    Barbara Brodsky

  2. Jean Baum is in the Department of Chemistry and Chemical Biology, BioMaPs Institute, Rutgers University, Piscataway, New Jersey 08854, USA. jean.baum@rutgers.edu,

    Jean Baum

Authors
  1. Barbara Brodsky
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  2. Jean Baum
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Brodsky, B., Baum, J. Modelling collagen diseases. Nature 453, 998–999 (2008). https://doi.org/10.1038/453998a

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