Living cells must do away with regulatory proteins that are not needed. News comes of a considerable advance in understanding how the main agent of destruction, the proteasome, catches its targets.
This is a preview of subscription content, log in via an institution to check access.
References
Husnjak, K. et al. Nature 453, 481–488 (2008).
Schreiner, P. et al. Nature 453, 548–552 (2008).
Pickart, C. M. & Cohen, R. E. Nature Rev. Mol. Cell Biol. 5, 177–187 (2004).
Deveraux, Q., Ustrell, V., Pickart, C. & Rechsteiner, M. J. Biol. Chem. 269, 7059–7061 (1994).
Elsasser, S. & Finley, D. Nature Cell Biol. 7, 742–749 (2005).
Wilkinson, C. R. et al. Nature Cell Biol. 3, 939–943 (2001).
Verma, R., Oania, R., Graumann, J. & Deshaies, R. J. Cell 118, 99–110 (2004).
Yao, T. et al. Nature Cell Biol. 8, 994–1002 (2006).
Hamazaki, J. et al. EMBO J. 25, 4524–4536 (2006).
Qiu, X. B. et al. EMBO J. 25, 5742–5753 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saeki, Y., Tanaka, K. Two hands for degradation. Nature 453, 460–461 (2008). https://doi.org/10.1038/453460a
Published:
Issue Date:
DOI: https://doi.org/10.1038/453460a
- Springer Nature Limited
This article is cited by
-
The plant hormone abscisic acid regulates the growth and metabolism of endophytic fungus Aspergillus nidulans
Scientific Reports (2018)
-
Interference with the 19S proteasomal regulatory complex subunit PSMD4 on the sperm surface inhibits sperm-zona pellucida penetration during porcine fertilization
Cell and Tissue Research (2010)
-
Characterization and tissue expression of channel catfish (Ictalurus punctatus Rafinesque, 1818) ubiquitin carboxyl-terminal hydrolase L5 (UCHL5) cDNA
Molecular Biology Reports (2010)