Circadian activity in the brain regulates the movement of blood stem cells into and out of the bone marrow. Perhaps this process is testing the suitability of these cell 'tenants' for their new home — the remodelling bone.
References
Méndez-Ferrer, S., Lucas, D., Battista, M. & Frenette, P. S. Nature 452, 442–447 (2008).
Shepherd, B. E. et al. Exp. Hematol. 32, 1040–1050 (2004).
Katayama, Y. et al. Cell 124, 407–421 (2006).
Sugiyama, T. et al. Immunity 25, 977–988 (2006).
D'Hondt, L. et al. J. Cell. Physiol. 200, 63–70 (2004).
Simmons, D. J. & Nichols, G. Jr Am. J. Physiol. 210, 411–418 (1966).
Fraser, W. D., Ahmad, A. M. & Vora, J. P. Curr. Opin. Nephrol. Hypertension 13, 437–444 (2004).
Fu, L. et al. Cell 122, 803–815 (2005).
Kai, T. & Spradling, A. Proc. Natl Acad. Sci. USA 100, 4633–4638 (2003).
Kai, T. & Spradling, A. Nature 428, 564–569 (2004).
Laird, D. J. et al. Cell 132, 612–630 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Scadden, D. Stem cells traffic in time. Nature 452, 416–417 (2008). https://doi.org/10.1038/452416a
Published:
Issue Date:
DOI: https://doi.org/10.1038/452416a
- Springer Nature Limited
This article is cited by
-
Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury
BMC Nephrology (2012)
-
An Evolving Model of Hematopoietic Stem Cell Functional Identity
Stem Cell Reviews and Reports (2012)