Many enzymes convert their substrates into organic radicals to allow challenging reactions to occur. A microbial enzyme does so by simple electron transfer, casting fresh light on enzyme evolution.
References
Kim, J., Darley, D. J., Buckel, W. & Pierik, A. J. Nature 452, 239–242 (2008).
Stubbe, J. & van der Donk, W. A. Chem. Rev. 98, 705–762 (1998).
Babior, B. M. Acc. Chem. Res. 8, 376–384 (1975).
Ehrenberg, A. & Reichard, P. J. Biol. Chem. 247, 3485–3488 (1972).
Buckel, W. & Keese, R. Angew. Chem. Int. Edn Engl. 34, 1502–1506 (1995).
Ragsdale, S. W. Chem. Rev. 103, 2333–2346 (2003).
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Jarrett, J. Radicals by reduction. Nature 452, 163–164 (2008). https://doi.org/10.1038/452163a
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DOI: https://doi.org/10.1038/452163a
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