In a tour-de-force demonstration of feasibility, a consortium of 50 research teams uses 500,000 genetic markers from each of 17,000 individuals to identify 24 genetic risk factors for 7 common human diseases.
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References
Wellcome Trust Case Control Consortium Nature 447, 661–678 (2007).
Buckwalter, J. A., Wohlwend, C. B., Colter, D. C., Tidrick, R. T. & Knowler, L. A. Surg. Gynecol. Obstet. 104, 176–179 (1957).
Carlson, C. S. et al. Am. J. Hum. Genet. 74, 106–120 (2004).
International HapMap Consortium Nature 437, 1299–1320 (2005).
Todd, J. A. et al. Nature Genet. doi:10.1038/ng2068 (2007).
Parkes, M. et al. Nature Genet. doi:10.1038/ng2061 (2007).
Zeggini, E. et al. Science doi:10.1126/science.1142364 (2007).
Saxena, R. et al. Science doi:10.1126/science.1142358 (2007).
Frayling, T. M. et al. Science doi:10.1126/science.1141634 (2007).
Hampe, J. et al. Nature Genet. 39, 207–211 (2007).
Rioux, J. D. et al. Nature Genet. 39, 596–604 (2007).
Tomlinson, I. P. & Bodmer, W. F. Trends Genet. 11, 493–498 (1995).
Cavalli-Sforza, L. Am. J. Hum. Genet. 25, 82–104 (1973).
Enattah, N. S. et al. Nature Genet. 30, 233–237 (2002).
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Bowcock, A. Guilt by association. Nature 447, 645–646 (2007). https://doi.org/10.1038/447645a
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DOI: https://doi.org/10.1038/447645a
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