In fruit flies, a few very large genes generate the small RNAs that silence parasitic DNA elements. These RNAs might also participate in an amplification circuit that increases their potency.
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References
Brennecke, J. et al. Cell 128, 1089–1103 (2007).
Gunawardane, L. S. et al. Science 315, 1587–1590 (2007).
Fire, A. et al. Nature 391, 806–811 (1998).
Hamilton, A. J. & Baulcombe, D. C. Science 286, 950–952 (1999).
Ketting, R. F., Haverkamp, T. H., van Luenen, H. G. & Plasterk, R. H. Cell 99, 133–141 (1999).
Tabara, H. et al. Cell 99, 123–132 (1999).
Djikeng, A., Shi, H., Tschudi, C. & Ullu, E. RNA 7, 1522–1530 (2001).
Vagin, V. V. et al. Science 313, 320–324 (2006).
Prud'homme, N., Gans, M., Masson, M., Terzian, C. & Bucheton, A. Genetics 139, 697–711 (1995).
Kim, V. N. Genes Dev. 20, 1993–1997 (2006).
Houwing, S. et al. Cell 129, 69–82 (2007).
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Zamore, P. Genomic defence with a slice of pi. Nature 446, 864–865 (2007). https://doi.org/10.1038/446864a
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DOI: https://doi.org/10.1038/446864a
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