Autophagy is the degradation of redundant or faulty cell components. It occurs as part of a cell's everyday activities and as a response to stressful stimuli, such as starvation. Connections with cellular life-and-death decisions and with cancer are now emerging.
Further Reading
Gozuacik, D. & Kimchi, A. Oncogene 23, 2891–2906 (2004).
Hippert, M., O'Toole, P. S. & Thorburn, A. Cancer Res. 66, 9349–9351 (2006).
Levine, B. Autophagy 2, 65–66 (2006).
Levine, B. & Klionsky, D. Dev. Cell 6, 463–477 (2004).
Lum, J. J., DeBarardinis, R. J. & Thompson, C. B. Nature Rev. Mol. Cell Biol. 6, 439–448 (2005).
Ogier-Denis, E. & Codogno, P. Biochim. Biophys. Acta 1603, 113–128 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Levine, B. Autophagy and cancer. Nature 446, 745–747 (2007). https://doi.org/10.1038/446745a
Published:
Issue Date:
DOI: https://doi.org/10.1038/446745a
- Springer Nature Limited
This article is cited by
-
The role of H3K27me3 methylation in cancer development
Genome Instability & Disease (2024)
-
Elucidating the molecular mechanisms underlying the induction of autophagy by antidepressant-like substances in C57BL/6J mouse testis model upon LPS challenge
Cell Communication and Signaling (2023)
-
Autophagy-targeted nanoparticles for effective cancer treatment: advances and outlook
NPG Asia Materials (2022)
-
P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition
Oncogene (2022)
-
Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment
Journal of Cancer Research and Clinical Oncology (2022)