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Molecular cannibalism

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The biosynthesis of vitamin B12 has fascinated generations of scientists, but part of the pathway was unknown. The missing enzymatic link has now been found, only to raise more mechanistic questions.

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Figure 1: A possible mechanism for the biosynthesis of a vitamin B12 fragment.

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Ealick, S., Begley, T. Molecular cannibalism. Nature 446, 387–388 (2007). https://doi.org/10.1038/446387a

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