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Organic chemistry

Synthesis undressed

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Fragile chemical groups can be shielded from harsh reaction conditions by temporary protection. This approach is conventional wisdom for organic synthesis, but is it always the best solution?

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Figure 1: Synthesis without protection.

References

  1. Baran, P. S., Maimone, T. J. & Richter, J. M. Nature 446, 404–408 (2007).

    Article  ADS  CAS  Google Scholar 

  2. Greene, T. W. & Wuts, P. G. M. Protective Groups in Organic Synthesis (Wiley-Interscience, New York, 2006).

    Google Scholar 

  3. Kocienski, P. J. Protecting Groups (Thieme, Stuttgart, 2003).

    Google Scholar 

  4. Hoffmann, R. W. Synthesis 3531–3541 (2006).

    Article  Google Scholar 

  5. Lichtenthaler, F. W. Angew. Chem. Int. Edn 31, 1541–1556 (1992).

    Article  Google Scholar 

  6. Hardegger, E. & Lohse, F. Helv. Chim. Acta 40, 2383–2389 (1957).

    Article  CAS  Google Scholar 

  7. Robinson, R. J. Chem. Soc. Trans. 111, 762–768 (1917).

    Article  CAS  Google Scholar 

  8. Nicolaou, K. C., Montagnon, T. & Snyder, S. A. Chem. Commun. 551–564 (2003).

  9. Whitesides, G. M. & Wong, C.-H. Aldrichim. Acta 16, 27–34 (1983).

    CAS  Google Scholar 

  10. Koeller, K. M. & Wong, C.-H. Nature 409, 232–240 (2001).

    Article  ADS  CAS  Google Scholar 

  11. Baran, P. S. & Richter, J. M. J. Am. Chem. Soc. 126, 7450–7451 (2004).

    Article  CAS  Google Scholar 

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Porco, J. Synthesis undressed. Nature 446, 383–385 (2007). https://doi.org/10.1038/446383a

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