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A channel sets the gain on pain

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Nerve impulses that convey pain signals to the brain are produced by sodium channels in the neuronal membrane. Studies on people who are unable to feel pain identify one specific sodium channel as essential to the process.

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Figure 1: Signalling through sodium channels.

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Authors and Affiliations

  1. Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, 06510, Connecticut, USA

    Stephen G. Waxman

  2. Center for Neuroscience and Regeneration Research, VA Hospital, West Haven, Connecticut

    Stephen G. Waxman

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  1. Stephen G. Waxman
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Waxman, S. A channel sets the gain on pain. Nature 444, 831–832 (2006). https://doi.org/10.1038/444831a

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