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HIV goes nuclear

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HIV-1 replicates itself by integrating into its host cell's DNA. Studies in cell culture reveal that nuclear-membrane proteins aid engagement of the viral DNA with that of its host before integration.

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Figure 1: HIV-1 integration into the host genome.

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Authors and Affiliations

  1. the Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Min Li & Robert Craigie

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  1. Min Li
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  2. Robert Craigie
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Li, M., Craigie, R. HIV goes nuclear. Nature 441, 581–582 (2006). https://doi.org/10.1038/441581a

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