A double-stranded break in DNA can profoundly destabilize a cell's genome. But how does the cell recognize the damage and halt division until it can be fixed? The answer lies in the proteins that package and unravel DNA.
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References
Tsukuda, T., Fleming, A. B., Nickoloff, J. A. & Osley, M. A. Nature 438, 379–383 (2005).
Keogh, M. C. et al. Nature 439, 497–501 (2006).
van Attikum, H., Fritsch, O., Hohn, B. & Gasser, S. M. Cell 119, 777–788 (2004).
Morrison, A. J. et al. Cell 119, 767–775 (2004).
Downs, J. A. et al. Mol. Cell 16, 979–990 (2004).
Murr, R. et al. Nature Cell Biol. 8, 91–99 (2006).
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. J. Biol. Chem. 273, 5858–5868 (1998).
Shroff, R. et al. Curr. Biol. 14, 1703–1711 (2004).
Fernandez-Capetillo, O., Lee, A., Nussenzweig, M. & Nussenzweig, A. DNA Repair (Amst.) 3, 959–967 (2004).
Chowdhury, D. et al. Mol. Cell 20, 801–809 (2005).
Celeste, A. et al. Nature Cell Biol. 5, 675–679 (2003).
Stucki, M. et al. Cell 123, 1213–1216 (2005).
Kusch, T. et al. Science 306, 2084–2087 (2004).
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Nussenzweig, A., Paull, T. Tails of histones lost. Nature 439, 406–407 (2006). https://doi.org/10.1038/439406a
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DOI: https://doi.org/10.1038/439406a
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