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Cancer biology

Signatures guide drug choice

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Cancer drugs are increasingly designed to target specific cell-signalling pathways. When, and in what combination, these drugs should be used might be judged by analysing the gene expression signature of the tumour.

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Figure 1: Oncogene activation, transcription signatures and drug sensitivity.

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Downward, J. Signatures guide drug choice. Nature 439, 274–275 (2006). https://doi.org/10.1038/439274a

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