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A new grammar for drug discovery

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To realize the potential of the genome for identifying candidate drugs we must move beyond individual genes and proteins. The signalling pathways in cells provide the right level for such analyses.

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Figure 1: Drug-discovery timeline.
Figure 2: Four signalling pathways linked to disease.

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Fishman, M., Porter, J. A new grammar for drug discovery. Nature 437, 491–493 (2005). https://doi.org/10.1038/437491a

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