Skip to main content
Log in

Cancer

One step at a time

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Traditional chemotherapy kills tumour cells directly; some newer drugs work instead by cutting the tumour's blood supply. An innovative approach combines these strategies sequentially to pack a double whammy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Step-by-step in fighting cancer.

References

  1. Hurwitz, H. et al. N. Engl. J. Med. 350, 2335–2342 (2004).

    Article  CAS  Google Scholar 

  2. Sengupta, S. et al. Nature 436, 568–572 (2005).

    Article  ADS  CAS  Google Scholar 

  3. Moses, M. A. et al. Cancer Cell 4, 337–341 (2003).

    Article  CAS  Google Scholar 

  4. Escudier, B. et al. Annu. Meet. Am. Soc. Clin. Oncol. abstr. LBA4510; http://www.asco.org/ac/1,1003,_12-002636-00_18-0034-00_19-0032211,00.asp (2005).

  5. Sandler, A. B. et al. Annu. Meet. Am. Soc. Clin. Oncol. abstr. LBA4; http://www.asco.org/ac/1,1003,_12-002643-00_18-0034-00_19-0033325,00.asp (2005).

  6. Demetri, G. D. et al. Annu. Meet. Am. Soc. Clin. Oncol. abstr. 4500; http://www.asco.org/ac/1,1003,_12-002643-00_18-0034-00_19-0034169,00.asp (2005).

  7. Jain, R. K. Adv. Drug Deliv. Rev. 46, 149–168 (2001).

    Article  CAS  Google Scholar 

  8. Blagosklonny, M. V. Cancer Cell 5, 13–17 (2004).

    Article  CAS  Google Scholar 

  9. Richardson, T. P., Peters, M. C., Ennett, A. & Mooney, D. J. Nature Biotechnol. 19, 1029–1034 (2001).

    Article  CAS  Google Scholar 

  10. Nori, A. & Kopecek, J. Adv. Drug Deliv. Rev. 57, 609–636 (2005).

    Article  CAS  Google Scholar 

  11. Kim, D. W., Lu, B. & Hallahan, D. E. Curr. Opin. Invest. Drugs 5, 597–604 (2004).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mooney, D. One step at a time. Nature 436, 468–469 (2005). https://doi.org/10.1038/436468a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/436468a

  • Springer Nature Limited

Navigation