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Metabolism

A higher power for insulin

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Glucose output from the liver is tightly regulated by insulin. But insulin holds sway over more than the liver — an unappreciated circuit in glucose control involves the opening of ion channels in the brain.

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Figure 1: Control of liver glucose production after a meal.

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  1. the Cambridge Institute for Medical Research and the Department of Clinical Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2XY, UK

    Fiona M. Gribble

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  1. Fiona M. Gribble
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Gribble, F. A higher power for insulin. Nature 434, 965–966 (2005). https://doi.org/10.1038/434965a

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